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. 2021 Feb 22;10:600762. doi: 10.3389/fonc.2020.600762

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Copyright © 2021 Zhu, Sun, Sun, Chen, Wu and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MLK3 is highly expressed in high-grade human glioma specimens. (A–C) MLK3 protein levels are upregulated in high-grade gliomas. (A) Representative immunohistochemistry IHC images of MLK3 in human glioma tissues. Scale bars, 50 μm. (B) MLK3 expression in para-tumor tissues (n = 25) and glioma tissues (n = 97). (C) Comparison of MLK3 expression between low-grade (grade I and II, n = 29) and high-grade (grade III and IV, n = 68) glioma tissues. Mann-Whitney U test. **P < 0.01. (D) The variation of MLK3 levels in the same grade gliomas. Mann-Whitney U test, **P < 0.01. (E, F) MLK3 mRNA levels are upregulated in high-grade gliomas. mRNA sequencing-based glioma datasets from Oncomine database (E) and the CGGA database (F) were analyzed by two-tailed Student’s t-tests and one-way ANOVA. NS, not significant. **P < 0.01. (G) The variation of MLK3 mRNA levels in the same grade gliomas. Two-tailed Student’s t-tests, **P < 0.01.