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. 2021 Feb 22;10:600762. doi: 10.3389/fonc.2020.600762

Figure 2.

Figure 2

High MLK3 levels are correlated with poor prognosis in patients with IDH-wt GBM. (A, B) High levels of MLK3 mRNA are prevalent in IDH-wt GBM. The frequencies of high MLK3 mRNA levels in IDH-wt gliomas (n = 136), primary GBM (n = 71), recurrent GBM (n = 15), and secondary GBM (n = 9) were analyzed. The data were derived from the CGGA dataset. The median level of MLK3 mRNA in glioma samples was chosen as the cut-off point. pGBM, primary GBM; rGBM, recurrent GBM; sGBM, secondary GBM. (C) MLK3 abundantly expressed in IDH-wt GBM. The percent of high MLK3 protein levels in IDH-wt gliomas (n = 57) was investigated. The data were obtained from IHC analysis. (D, E) High levels of MLK3 mRNA are associated with the poor prognosis of patients. Kaplan-Meier survival analyses for MLK3 mRNA expression (n = 286) (D) and MLK3 mRNA expression and IDH gene status (n = 286) (E). The data were derived from the CGGA dataset. Log-rank test. NS, not significant. *P < 0.05, **P < 0.01.