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. 2021 Feb 22;12:620012. doi: 10.3389/fendo.2021.620012

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Copyright © 2021 Vetrivel, Zhang, Engel, Altieri, Braun, Osswald, Bidlingmaier, Fassnacht, Beuschlein, Reincke, Chen, Sbiera and Riester

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed miRNAs from NGS of preoperative group. Volcano plot showing the relationship between fold change (log2foldchange) and statistical significance (−log10pvalue). The red points in the plot represent the differentially expressed miRNAs with FDR <0.05 considered as statistically significant. CPA, cortisol producing adenoma; CD, Cushing’s Disease, CS, Cushing syndrome represents CPA and CD, taken together. Volcano plot showing the relationship between fold change (log2foldchange) and statistical significance (-log10pvalue) for the groups CS vs Controls (A), CPA vs. Controls (B), CD vs. Controls (C), CPA vs CD (D).