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. 2021 Feb 22;12:533028. doi: 10.3389/fphar.2021.533028

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Copyright © 2021 Gu, Chen, Fu, Liu, Wang, Liu and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isoflavones reduced the rate of cell death in primary cultured neurons under OGD/RO or l-glutamate-challenges. Rate of cell death was determined with LDH release assay. Isoflavones including calycosin (C), formononetin (F) and daidzein (D) were added into cultured media at the indicated concentrations prior to OGD/RO or l-glutamate (Glu) exposures. (A) Primary cultured mature neurons (DIV10) were exposed to 4 h OGD followed by 20 h RO. (B) Neurons were treated with 8 mM l-glutamate for 6 h. “Veh” means vehicle control that receives same volume of dissolvent. Data were represented as Mean ± SD, n = 4 (*p < 0.05, ^** p < 0.01, compared to vehicle control).