Table 3.

Use of hepatitis B core as a vaccine platform to display epitopes in several expression systems.

Pathogen	Epitope(s)	Expression system	Site of epitope insertion	Ref.
Dengue virus	cEDIII	N. benthamiana	MIR	[68]
H1N1 Influenza A virus	matrix protein 2	E. coli	MIR	[188]
H7N9 Influenza	long alpha-helix (LAH)	E. coli	MIR	[189]
Mycobacterium Tuberculosis (Tuberculosis)	Culture filtrate protein 10 (CFP 10)	E. coli	MIR	[190]
–	Hepatitis B Core Antigen	E. coli	MIR	[86]
		Nicotiana benthamiana
	GGS sequence
Influenza virus	M2e	E. coli	MIR	[191]
Influenza virus	M2e	N. benthamiana	N-terminal	[192]
Dengue virus	EDIII-2	E. coli	MIR	[193]
Dengue virus	EDIII	E. coli	MIR	[193]
Hepatitis C virus	HCc N-terminus	E. coli	C-terminal	[194]
Influenza A	M2e	E. coli	N-terminal	[195]
Hepatocellular carcinoma	HBV X protein	E. coli	C-terminal, MIR	[196]
Hepatocellular carcinoma	AFP1, AFP2	E. coli	C-terminal	[197]
Hepatitis C virus	HCc T-cell epitope	E. coli	MIR	[198]
Foot-and-mouth-disease virus	VP1, VP4	N. tabacum, E. coli	MIR	[199,200]
Hepatitis B virus	Pre-S1	E. coli	MIR	[201]
Hantavirus	Nucleocapsid protein	E. coli	MIR	[202]
Hepatitis B virus	Pre-S1	E. coli	C-terminal	[203]
Human Papillomavirus	E7	E. coli	C-terminal	[204]
Theileria annulata	SPAG-1	E. coli	MIR	[205]
Human Immunodeficiency Virus	Gag	E. coli	N-terminal	[206]
Human Immunodeficiency Virus	Env	E. coli	C-terminal	[90]
Foot-and-mouth-disease virus	VP1	E. coli	N-terminal	[67]