Table 2.
Characteristics of 19 patients with myelodysplastic syndromes (MDS) and nephropathies documented by kidney biopsy, including seven patients with tubule-interstitial nephritis and twelve with glomerulopathies. Values are medians (range) or percentages
| Characteristics | Tubulo-interstitial nephritis (n = 7) | Glomerulopathy (n = 12) | All (n = 19) |
|---|---|---|---|
| Age (years) | 76 (74-83) | 73.5 (63-80) | 74 (63-83) |
| Female | 1 (14%) | 4 (33.3%) | 5 (26%) |
| Chemotherapy at the time of kidney biopsy | 2 (29%) | 1 (8.3%) | 3 (16%) |
| Time between MDS and kidney biopsy (years) | 1.6 (0-7) | 1 (0-7) | 1.5 (0-7) |
| Serum creatinine (mg/dl) | 3.6 (1.9-8.3) | 2.1 (0.6-5.1) | 2.75 (0.6-8.3) |
| Urinary Protein/Creatinine (g/g) | 1.05 (0.6-4.7) | 1.2 (0.2-11) | 1.2 (0.2-11) |
| Haematuria | 5 (71%) | 10 (83%) | 15 (79%) |
| Extra-renal manifestations | 4 (57%) | 7 (58%) | 11 (58%) |
| Treatment | |||
| Immunosuppression | 3 (43%) | 8 (67%) | 11 (58%) |
| Supportive care | 4 (57%) | 4 (33%) | 8 (42%) |
| Outcome | |||
| Remission | 1 (14%) | 1 (8%) | 2 (11%) |
| Chronic kidney disease | 3 (43%) | 6 (50%) | 9 (47%) |
| Dialysis | 2 (29%) | 3 (25%) | 5 (26%) |
| Death | 1 (14%) | 2 (17%) | 3 (16%) |