Table 2.

Laboratory data before HSCT and after HSCT at diagnosis of FS

Laboratory parameter (reference range)	Case 1	Case 2	Case 3	Case 4	Case 5
Before HSCT
Kappa light chain (0.33–1.94 mg/dl)	4.8	1.71	0.678	<0.0061	57.7
Na+ (135–145 mmol/l)	142	137	141	142	145
K+ (3.6–5.2 mmol/l)	3.8	5.2	4.6	4.5	3.7
Cl− (98–107 mmol/l)	100	103	101	102	104
HCO3− (22–29 mmol/l)	33	23	28	24	22
Anion gap (7–15)	9	11	12	16	19
Mg2+ (1.7–2.3 mg/dl)	1.5	1.5	1.9	1.6	1.7
PO43− (2.5–4.5 mg/dl)	4.4	4.8	2.5	3	3.3
Uric acid (3.7–8.0 mg/dl)	7.6	9.9	4.7	N/A	4.2
Creatinine (0.74–1.35 mg/dl)	1.1	1.7	0.9	0.77	1.7
Creatinine-based eGFR (≥60 ml/min/BSA)	54	41	67	105	42
Glucose (70–140 mg/dl)	99	124	116	86	140
Urine glucose (0–15 mg/dl)	4	19	17	17	22
Predicted 24-hour urine total protein (mg)	112	696	166	361	2706
After HSCT at diagnosis of FS
Kappa light chain (0.33–1.94 mg/dl)	14	0.374	2.23	0.0483	28.5
Na+ (135–145 mmol/l)	140	140	143	135	141
K+ (3.6–5.2 mmol/l)	3.2	4.6	2.6	3.3	3.2
Cl− (98–107 mmol/l)	111	116	103	107	116
HCO3− (22–29 mmol/l)	19	17	26	16	13
Anion gap (7-15)	10	7	14	12	12
Mg2+ (1.7–2.3 mg/dl)	1.3	1.6	1.6	1.3	1.5
PO43− (2.5–4.5 mg/dl)	1.9	3.3	1	1.1	1
Uric acid (3.7–8.0 mg/dl)	N/A	7.8	1.5	1.3	4.6
Creatinine (0.74–1.35 mg/dl)	2.2	3.4	0.6	1.01	2.07
Creatinine-based eGFR (≥60 ml/min/BSA)	25	18	67	86	33
Glucose (70–140 mg/dl)	91	N/A	121	83	126
Urine glucose (0–15 mg/dl)	26	26	151	306	12
Predicted 24-hour urine total protein, mg	1848	846	857	2350	1540
Random urine electrolytes
Na+, mmol/l	117	N/A	140	N/A	37
K+, mmol/l	30		14		33
Cl−, mmol/l	135		90		32
Mg2+, mg/dl			49
PO43−, mg/dl			66
Creatinine, mg/dl	62		64		89
Urine anion gap	50	N/A	N/A	30	38
Random urine K+/creatinine ratio,a mEq/mmol	5.47	N/A	2.5	N/A	4.19
FeMg2+, %	N/A	N/A	4b	N/A	N/A
FePO43-, %	N/A	N/A	61.88c	N/A	N/A
24-hour urine electrolytes
Na+ (41–227 mmol/day)	N/A	N/A	N/A	338	N/A
K+ (17–77 mmol/day)				109d
Cl− (40–224 mmol/day)				417
Mg2+ (51–269 mg/day)				225e
PO43− (<1100 mg/day)				413f
Creatinine (601–1689 mg/day)				1202

FS, Fanconi syndrome; HSCT, hematopoietic stem cell transplantation; N/A, not applicable.

^aA random urine K⁺/creatinine ratio of >2.5 mEq/mmol suggests inappropriate response by the kidneys to hypokalemia and kidney K⁺ wasting.

^bA FeMg²⁺ of >3% suggests inappropriate response by the kidneys to hypomagnesemia and kidney Mg²⁺ wasting.

^cA FePO₄³⁻of >5% suggests inappropriate response by the kidneys to hypophosphatemia and kidney PO₄³⁻ wasting.

^dA 24-hour urine K⁺ of >25–30 mmol/day suggests inappropriate response by the kidneys to hypokalemia and kidney K⁺ wasting.

^eA 24-hour urine Mg²⁺ of >10–30 mg/day suggests inappropriate response by the kidneys to hypomagnesemia and kidney Mg²⁺ wasting.

^fA 24 hour urine PO₄³⁻ of >100 mg/day suggests inappropriate response by the kidneys to hypophosphatemia and kidney PO₄³⁻ wasting.