Table 1.
Baseline characteristics of the Boston Kidney Biopsy Cohort (n = 523)
| Baseline characteristics | |
|---|---|
| Plasma biomarker concentrations, pg/ml | |
| sTNFR-1 | 1012.7 [485.1, 2167.8] |
| sTNFR-2 | 6097.6 [3301.5, 12411.6] |
| YKL-40 | 53.5 [25.7, 98.6] |
| MCP-1 | 135.2 [95.3, 193.1] |
| suPAR | 3044.3 [1809.8, 6493.2] |
| Clinical characteristics | |
| Age, yr | 52.8 ± 16.6 |
| Female | 266 (50.9) |
| Race | |
| White | 333 (63.7) |
| Black | 104 (19.9) |
| Other | 86 (16.4) |
| eGFR, ml/min per 1.73 m2 | 56.4 ± 36.0 |
| Serum creatinine, mg/dl | 1.5 [0.9–2.3] |
| Proteinuria, g/g creatinine | 1.6 [0.4, 3.9] |
| Reason for biopsya | |
| Proteinuria | 305 (58.3) |
| Hematuria | 127 (24.3) |
| Nephrotic syndrome | 69 (13.2) |
| Nephritic syndrome | 12 (2.3) |
| Abnormal eGFR | 268 (51.2) |
| Primary clinicopathologic diagnosisb | |
| Proliferative glomerulonephritis | 150 (29.2) |
| Nonproliferative glomerulopathy | 93 (18.1) |
| Advanced glomerulosclerosis | 58 (11.3) |
| Diabetic kidney disease | 57 (11.1) |
| Vascular disease | 44 (8.6) |
| Paraprotein-related disease | 42 (8.2) |
| Tubulointerstitial disease | 39 (7.6) |
| Other | 31 (6.0) |
| Comorbid conditions | |
| Diabetes mellitus | 120 (22.9) |
| Hypertension | 278 (53.2) |
| Systemic lupus erythematosus | 77 (14.7) |
| Systemic vasculitis | 13 (2.5) |
| Hepatitis B | 4 (0.8) |
| Hepatitis C | 10 (1.9) |
| Malignancy | 82 (15.7) |
| Human immunodeficiency virus | 5 (1.0) |
| Non-kidney solid organ transplant | 9 (1.7) |
| Medications | |
| ACEi/ARB | 242 (46.3) |
| MRA | 12 (2.3) |
| Calcium channel blockers | 137 (26.2) |
| Beta-blockers | 168 (32.1) |
| Immunosuppression | 94 (18.0) |
| Corticosteroids | 97 (18.5) |
| Immunosuppression or corticosteroids | 150 (28.7) |
| Clinical site | |
| Site 1 | 333 (63.7) |
| Site 2 | 118 (22.6) |
| Site 3 | 72 (13.8) |
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; eGFR, estimated glomerular filtration rate; MRA, mineralocorticoid receptor antagonist.
Data are presented as mean ± standard deviation, median [interquartile range], and count with frequencies (%) for binary and categorical variables.
a
Percentages do not add to 100 as there may have been more than 1 reason for kidney biopsy.
b
Nine individuals had insufficient tissue to make a clinicopathologic diagnosis; the “other diagnosis” category was composed of participants with minor abnormalities or relatively preserved parenchyma.