Table 2.
Meta-analysis of the association of genetic variants in enamel-formation genes with the risk of dental caries.*
| Genetic variant* | Gene | Number of studies | Number of study subjects |
Test of heterogeneity | OR (95% CI) | P | |
|---|---|---|---|---|---|---|---|
| Dental caries | Control | ||||||
| rs12640848 | ENAM | 7 | 1256 | 710 | 7.69 × 10−25 | 1.15 (0.88–1.52) | 0.310 |
| rs1784418 | MMP20 | 5 | 699 | 817 | 1.38 × 10−20 | 1.07 (0.76–1.49) | 0.702 |
| rs17878486 | AMELX | 4 | 249 | 193 | 3.58 × 10−4 | 1.40 (1.02–1.93) | 0.037 |
| rs3796704 | ENAM | 4 | 574 | 533 | 0.091 | 1.06 (0.96–1.17) | 0.228 |
We only reported results for genetic variants that had data from at least four studies. Results for other genetic variants assuming different genetic models were reported in Supplementary Tables 1–5.
OR: odds ratio; CI: confidence interval.
*
Assuming an additive genetic model.