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. 2021 Mar 3;16:1805–1817. doi: 10.2147/IJN.S295598

Scheme 1.

Scheme 1

Schematic illustration for the synthesis of As-TDN-R. Aptamer AS1411 is linked on the strand of s1 for selective delivery into the glioma cells. siRNA-R binds to survivin mRNA, inducing apoptosis of glioma. Inline graphic represents aptamer AS1411. Inline graphic represents complementary strand of siRNA-R; Inline graphic represents siRNA-R strand.