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. 2021 Feb 22;11:624809. doi: 10.3389/fphar.2020.624809

FIGURE 2.

FIGURE 2

High glucose concentration was cell-damaging and abolished SPostC-induced cardioprotection. (A) Cell viability: Compared with N + H/R group, N + H/R + SPostC group improved cell viability, but H + H/R + SPostC group failed to increase cell viability (n = 5/group). (B) LDH activity: Compared to N + H/R group, N + H/R + SPostC group significantly reduced LDH content, but H + H/R + SPostC group failed to reduce LDH content (n = 3/group). (C,D) Flow cytometry to measure apoptosis: Compared with N + H/R group, N + H/R + SPostC group reduced cell apoptosis, but H + H/R + SPostC group failed to effectively reduce cell apoptosis (n = 3/group). Data represent mean ± SD, vs. N + CON group * p < 0.05; vs. N + H/R group # p < 0.05; vs. N + H/R + SPostC group ^ p < 0.05; vs. N + H/R + SPostC + YC-1 group & p < 0.05; vs. N + H/R + SPostC + ISO-1 group % p < 0.05; vs. H + CON group a P < 0.05; vs. H + H/R group b P < 0.05; vs. H + H/R + SPostC group c P < 0.05.