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. 2021 Feb 22;11:624809. doi: 10.3389/fphar.2020.624809

FIGURE 4.

FIGURE 4

SPostC exerts its cardioprotective effect by HIF-1α/MIF/AMPK signal pathway under low glucose condition, but the function is inactivated under high glucose condition. (A) Western blot images of each group under normal glucose condition; (B) Western blot images of each group under high glucose condition; Under normal culture, SPostC significantly upregulated HIF-1a, MIF and p-AMPKα protein expression. After YC-1 and IOS-1 administration, the expression of HIF-1a MIF and p-AMPKα was downregulated. Data represent mean ± SD, vs. N + CON group *p < 0.05; vs. N + H/R group # p < 0.05; vs. N + H/R + SPostC group ^ p < 0.05; vs. N + H/R + SPostC + YC-1 group & p < 0.05; vs. H + control group a P < 0.05; vs. H + H/R group b P < 0.05; vs. H + H/R + SPostC group c P < 0.05.