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. 2021 Feb 22;11:624809. doi: 10.3389/fphar.2020.624809

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Copyright © 2021 Ma, Li, Hou, Li, Yang, Guo, Li, Xin and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulate HIF-1α/MIF/AMPK signaling pathway restored SPostC-induced cardioprotective effects in a high glucose condition. (A) ROS synthesis: Compared with N + H/R group, N + H/R + SPostC group reduced ROS synthesis, but H + H/R + SPostC group failed to reduce ROS synthesis; Compared with N + H/R + SPostC group, YC-1 group and IOS-1 group promoted ROS synthesis; Compared with H + H/R + SPostC group, DMOG group and MIF20 group reduced ROS synthesis (n = 3/group). (B) ATP content: Compared with N + H/R group, N + H/R + SPostC group significantly increased ATP content, but H + H/R + SPostC group ATP content decreased; compared with N + H/R + SPostC group, YC-1 group and IOS-1 group decreased ATP content; compared with H + H/R + SPostC group Compared with DMOG group and MIF20 group, ATP content increased (n = 3/group). (C) Representative images of JC-1 were capture using a fluorescence inverted microscope in cardiomyocytes (200×). The results showed that HIF-1α agonist DMOG and MIF agonist MIF20 increased the ratio of red to green fluorescence intensity (n = 3/group). Data represent mean ± SD, vs. N + CON group *p < 0.05; vs. N + H/R group #p < 0.05; vs. N + H/R + SPostC group ^p < 0.05; vs. N + H/R + SPostC + YC-1 group & p < 0.05; vs. N + H/R + SPostC + ISO-1 group %p < 0.05; vs. H + control group ^a P < 0.05; vs. H + H/R group ^b P < 0.05; vs. H + H/R + SPostC group ^c P < 0.05.