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. 2021 Feb 26;14(4):38. doi: 10.3892/br.2021.1414

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Copyright: © Liang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of GBE on HIF-1α and TGF-β1 expression in rat renal tissues. The expression of HIF-1α and TGF-β1 was detected using immunohistochemical staining and quantified. (A and C) Representative images of immunohistochemically stained renal tissue sections. Magnification, x400. HIF-1α and TGF-β1 protein expression was primarily observed in the renal tubular epithelial cells. (B and D) Quantitative analysis of HIF-1α and TGF-β1 proteins expression levels in renal tissues, respectively. Data are presented as the mean ± standard deviation. n=9. ^*P<0.05 vs. CDDP group, ^#P<0.05 vs. CDDP + GBE group. GBE, Ginkgo biloba extract; SB, SB203580; HIF-1α, hypoxia inducible factor-1α.