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. 2021 Feb 22;10:592239. doi: 10.3389/fonc.2020.592239

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Copyright © 2021 Jin, Zhou, Chen, Dai, Fu, Yang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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qPCR results show that TROAP knockdown inhibited TWIST expression (A). GSEA analysis of TROAP coexpressed genes showed that c-Myc and E2F1 signals were correlated with TROAP expression (B). TWIST could bound to the promoter regions of E2F1 and c-Myc to regulate E2F1 and c-Myc expression (C). TWIST knockdown could inhibit the expression of c-Myc and had no effect on expression of E2F1 (D). Analysis of the TCGA database showed a correlation between TWIST and c-Myc (E). TROAP knockdown suppressed TWIST and c-Myc expressions at the levels of mRNA and protein (F, G). TROAP expression was positively correlated with TWIST and c-Myc expressions (H, I). **P < 0.01, ***P < 0.001. ns means no significance.