Table 1.
List of immunodeficient mice used as recipients for transplantation of human hemato-lymphoid system.
| Acronym |
Genetic background |
T and B cell deficiency |
NK cell deficiency |
Phagocytic tolerance |
References |
|---|---|---|---|---|---|
| SCID | C.B-17 | Prkdcscid | - | - | (12, 25, 26) |
| NOD-SCID | NOD | Prkdcscid | - | SirpaNOD | (40, 41) |
| BRG | Balb/c | Rag2−/− | Il2rg−/− | - | (21, 32) |
| NOG | NOD | Prkdcscid | Il2rg−/− (truncation) | SirpaNOD | (35) |
| NSG | NOD | Prkdcscid | Il2rg−/− | SirpaNOD | (33, 34) |
| NRG | NOD | Rag1−/− | Il2rg−/− | SirpaNOD | (42) |
| BRGSNOD | Balb/c | Rag2−/− | Il2rg−/− | SirpaNOD | (43) |
| StgRG | Balb/c x 129 | Rag2−/− | Il2rg−/− | Human SIRPA (BAC tg) | (45) |
| SKIRG | Balb/c x 129 | Rag2−/− | Il2rg−/− | Human SIRPA (KI extracellular domain) | (46) |
| B6RGSNOD | C57BL/6 | Rag2−/− | Il2rg−/− | SirpaNOD | (44) |
| B6RGSHuman | C57BL/6 | Rag2−/− | Il2rg−/− | Human SIRPA (KI full-length) | (47) |
| B6RG-CD47 | C57BL/6 | Rag2−/− | Il2rg−/− | Cd47−/− | (48) |
SCID, NOD-SCID and BRG are historical models, that provided the basis for most currently used recipient mice. All other mice listed in this table have conceptually similar properties, with a few exceptions, as discussed in the text.