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. 2021 May 24;5:111. Originally published 2020 Jun 1. [Version 2] doi: 10.12688/wellcomeopenres.15846.2

Figure 2. Genotype-by-sex interaction results within the HHIP region for lung function traits in UK Biobank.

Figure 2.

The SNP with the strongest association in the rs7697189-proximal region is represented by a blue diamond. The FEV 1 and PEF sentinels are rs7697189, the FEV 1/FVC sentinel is rs1512281 (R 2 = 0.95 with rs7697189), and the FVC sentinel is rs7681384 (R 2 = 0.57 with rs7697189). Note that there is an independent suggestively significant signal from rs2353939 and surrounding SNPs for FVC, but this did not replicate in SpiroMeta cohorts. All other SNVs are colour coded according to their linkage disequilibrium (R 2) with the sentinel SNP (as shown in the key). All imputed SNVs are plotted irrespective of MAF, demonstrating that rarer variants are not exhibiting significant interactions with sex on lung function. The locations of genes in the region are shown in the lower panel of each plot. Recombination rate is represented by the blue lines. These plots were generated using LocusZoom software.