Table 1.
Baseline characteristics and 7-day and 90-day stroke risk in non-consensus TIA, classic TIA, and minor stroke
| Non-consensus TIA (n=570) | Classic TIA (n=1021) | Minor stroke (NIHSS <5; n=1287) | p value (non-consensus TIA vs classic TIA) | Age-adjusted p value | ||
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, years | 68·5 (14·1) | 72·9 (13·6) | 72·4 (13·9) | <0·0001 | .. | |
| Sex | .. | .. | .. | 0·87 | 0·57 | |
| Male | 281 (49%) | 499 (49%) | 664 (52%) | .. | .. | |
| Female | 289 (51%) | 522 (51%) | 623 (48%) | .. | .. | |
| Clinical characteristics | ||||||
| Comorbidities | ||||||
| Hypertension | 287 (50%) | 558 (55%) | 715 (56%) | 0·099 | 0·99 | |
| Diabetes | 54 (9%) | 116 (11%) | 183 (14%) | 0·24 | 0·40 | |
| Hyperlipidaemia | 151 (26%) | 300 (29%) | 358 (28%) | 0·22 | 0·43 | |
| Atrial fibrillation* | 63 (11%) | 186 (18%) | 219 (17%) | <0·0001 | 0·010 | |
| Current smoker | 74 (13%) | 136 (13%) | 241 (19%) | 0·85 | 0·095 | |
| Coronary heart disease | 66 (11%) | 193 (19%) | 250 (19%) | <0·0001 | 0·015 | |
| Peripheral vascular disease | 21 (4%) | 53 (5%) | 83 (6%) | 0·17 | 0·45 | |
| Previous stroke | 24 (4%) | 69 (7%) | 124 (10%) | 0·038 | 0·12 | |
| Medication before event | ||||||
| Antithrombotic | 177 (31%) | 379 (37%) | 488 (38%) | 0·015 | 0·45 | |
| Antihypertensive | 281 (49%) | 555 (55%) | 732 (57%) | 0·053 | 0·99 | |
| Statin | 148 (26%) | 315 (31%) | 359 (28%) | 0·040 | 0·29 | |
| Stroke risk from time of index event | ||||||
| 7-day events | 38/570 | 90/1021 | 42/1287 | .. | .. | |
| 7-day risk | 6·7% (5·7–8·7) | 8·8% (7·0–10·6) | 3·3% (2·3–4·3) | 0·12 | 0·14 | |
| 90-day events | 59/570 | 118/1021 | 93/1287 | .. | .. | |
| 90-day risk | 10·6% (7·8–12·9) | 11·6% (9·6–13·6) | 7·2% (5·8–8·6) | 0·43 | 0·55 | |
| Stroke risk from time of seeking medical attention† | ||||||
| 7-day events | 15/521 | 53/986 | 38/1346 | .. | .. | |
| 7-day risk | 2·9% (1·5–4·3) | 5·5% (5·0–6·8) | 2·8% (1·8–3·8) | 0·025 | 0·025 | |
| 90-day events | 19/521 | 70/986 | 83/1346 | .. | .. | |
| 90-day risk | 3·6% (2·1–5·1) | 7·1% (5·5–8·7) | 6·2% (4·8–7·6) | 0·0070 | 0·019 | |
Data are mean (SD), n (%), n/N, or % (95% CI). NIHSS=National Institutes of Health Stroke Score. TIA=transient ischaemic attack.
*
Patients with known atrial fibrillation before diagnosis or new atrial fibrillation at baseline assessment.
†
The analysis of stroke risk from time of seeking medical attention excludes 25 patients who presented with a major stroke and is stratified by the nature of the presenting event rather than the index event.