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. 2021 Mar 4;41(3):BSR20202828. doi: 10.1042/BSR20202828

Figure 1. Composition of the NatC complex.

Figure 1

(A) NatC is a trimeric protein complex that consists of the catalytic subunit NAA30 (Mak3), the ribosomal anchor NAA35 (Mak10), and the auxiliary subunit NAA38 (Mak31). The yeast protein names are given in parenthesis. During protein synthesis, NatC can N-terminally acetylate proteins beginning with methionine followed by a hydrophobic or amphipathic amino acid (e.g. for human NAA30 L, I, F, W, V, M and K). Hydrophobic residues are represented by the Φ letter. (B) Sequence alignment of human NAA30 and yeast Mak3. The acetyl-CoA-binding domain (RxxGxG/A) is indicated with a red box. Human NAA30 has an N-terminal extension that is not present in the yeast Mak3.