Table 4.
The number of patients (%) with Cmax1 after different Tmax1
| Group | Auvi-Q® 1 | Auvi-Q® 2 | Epipen® |
|---|---|---|---|
| Minutes | n 69 (%) | 66 (%) | 67 (%) |
| 3–9 | 31 (45) | 30 (43) | 24 (36) |
| 0–15 | 40 (58) | 41 (61) | 29 (43) |
| 15–27 | 7 (10) | 4 (6) | 9 (13) |
| 27–39 | 10 (14) | 13 (20) | 15 (22) |
| 39–60 | 12 (17) | 8 (12) | 14 (21) |
A majority of patients had a Tmax1 less than 15 min, i.e. epinephrine reached the circulation in time to counteract the effects of general allergic reactions/anaphylaxis. A majority of these patients reached a Cmax1 before 10 min post injection. The same patients were injected once with Epipen® and twice with Auvi-Q®. Modified after Edwards [10] Table 3. Edwards gave the time in decimals of an hour; we modified to minutes and grouped data into fewer groups