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. 2021 Mar 8;18:11. doi: 10.1186/s12979-021-00223-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Age-related differences in monocyte DNA methylation in Kenyan adults and children. Monocytes were negatively selected from fresh venous blood samples from healthy Kenyan children (n = 8) and adults (n = 8). a Principal components analysis (PCA) plot of DNA methylation results for Kenyan adult (red) and child (blue) monocytes. b Heatmap of DNA methylation results showing differentially methylated positions between Kenyan adult and child monocytes, includes all CpG probe sites meeting differential methylation criteria (absolute beta value difference > 0.15, p < 0.01, and FDR-adjusted p < 0.05). c Plot of differentially methylated region in the CLEC12A gene locus, showing beta values for Kenyan adult (red) and child (blue) monocytes at 6 CpG probe sites within the region. d KEGG pathway enrichment analysis of genes associated with differentially methylated positions in monocytes from Kenyan adults vs. children, showing the most significantly enriched pathways