Table 1.
Perinatal Characteristics, Neonatal Morbidities and Laboratory Result
| Control (n = 49) | I (n = 45) | P-value | |
|---|---|---|---|
| Gestational age (week) | 29+ 2 (24+ 1, 34+ 2) | 26+ 6 (24+ 0, 33+ 1) | < 0.001* |
| Birth weight (g) | 1090 (540, 1340) | 770 (420, 1400) | < 0.001* |
| Birth HC (z-score) | −0.49 (− 3.28, 2.55) | − 0.61 (−4.26, 0.98) | 0.255 |
| Male | 20 (40.8) | 28 (62.2) | 0.100 |
| Multiple birth | 21 (42.9) | 20 (44.4) | 0.877 |
| Apgar score | |||
| At 1 min | 5 (1, 8) | 3 (0, 8) | 0.028* |
| At 5 min | 7 (1, 9) | 7 (0, 9) | 0.004* |
| Cesarean section | 33 (67.3) | 28 (62.2) | 0.440 |
| PROM | 10 (20.4) | 7 (15.6) | 0.541 |
| HCA | 19 (38.8) | 21 (46.7) | 0.440 |
| Preeclampsia | 2 (4.1) | 3 (6.7) | 0.577 |
| Antenatal steroid | 42 (85.7) | 41 (91.1) | 0.294 |
| SGA | 14 (28.6) | 15 (33.3) | 0.618 |
| RDS | 26 (53.1) | 35 (77.8) | 0.012* |
| Moderate to severe BPD | 11 (22.4) | 30 (66.7) | < 0.001* |
| PDA operation | 2 (4.1) | 14 (31.1) | < 0.001* |
| ROP ≥ stage III | 2 (4.1) | 15 (33.3) | < 0.001* |
| IVH, grade III | 0 (0.0) | 2 (4.4) | 0.136 |
| Culture Proven Sepsis | 0 (0.0) | 11 (24.4) | < 0.001* |
| NEC ≥ stage II | 0 (0.0) | 2 (4.44) | < 0.001* |
| The number of Inflammatory episode | 1 (1, 6) | – | |
| Postnatal days of Inflammatory episode | 17 (0, 85) | – | |
| WBC (×103/μl) | – | 11.44 (1.00, 39.00) | – |
| I/T ratio | – | 0.00 (0.00, 0.89) | – |
| Platelet (×103/μl) | – | 157 (30, 811) | – |
| CRP (mg/dL) | – | 1.96 (0.01, 18.21) | – |
Values are presented as median (min, max), or number (%)
HC head circumference; PROM premature rupture of membranes; HCA histologic chorioamnionitis; SGA small for gestational age; RDS respiratory distress syndrome; BPD bronchopulmonary dysplasia; PDA patent ductus arteriosus; ROP retinopathy of prematurity; IVH intraventricular hemorrhage; I/T ratio immature to total neutrophil ratio; CRP C-reactive protein
* p < 0.05