Table 2.
Short-term Neurological and CA of 18 months Neurodevelopmental Outcome
| Control (n = 49) | I (n = 45) | P-value† | P-value§ | |
|---|---|---|---|---|
| HC at PMA 36 weeks (z-score) | −1.45 (−3.92, 0.51) | −2.12 (−5.28, 0.17) | < 0.001* | 0.049* |
| aEEG at PMA 35 weeks | ||||
| Maturation score | 9.50 (4, 13) | 8 (4, 12) | 0.002* | 0.017* |
| WMI on MRI at discharge | 0.008* | 0.036* | ||
| None | 48 (98) | 33 (73.3) | ||
| Mild | 1 (2) | 8 (17.8) | ||
| Moderate to severe | 0 (0) | 4 (8.9) | ||
| HC at a CA of 18 months (z-score) | 0.32 (−2.42, 2.36) | − 0.88 (−3.91, 2.13) | < 0.001* | 0.005* |
| Bayley-III and Cerebral palsy at a CA of 18 months | ||||
| Cognitive | 95 (85, 125) | 90 (55, 120) | 0.006* | 0.076 |
| Language | 97 (74, 121) | 89 (50, 121) | 0.015* | 0.108 |
| Motor | 100 (82, 118) | 91 (46, 110) | 0.002* | 0.029* |
| Social Emotional | 95 (80, 110) | 90 (55, 115) | 0.066 | 0.311 |
| Adaptive Behaviour | 92 (61, 115) | 84 (48, 111) | 0.005* | 0.055 |
| Cerebral palsy | 2 (4.0) | 6 (13.3) | 0.080 | 0.240 |
Values are presented as average (min, max), or number (%)
†P-values are adjusted for gestational age
§P-values are adjusted for gestational age, Apgar score, RDS, BPD, PDA operation, ROP (≥stage III), and IVH (≥Grade III)
HC head circumference; aEEG amplitude-integrated EEG; PMA Postmenstrual age; WMI White matter injury; MRI magnetic resonance imaging; CA corrected age, Bayley-III Bayley Scales of Infant and Toddler Development III
* p < 0.05