Table 5.

Correlation between Biomarkers (Day 0) and Neurodevelopment (CA of 18 months) in the Inflammation Group

	I/T ratio	let	CRP	IL-1 beta		IL-8		TNF alpha		S100B		Enolase2		MBP
				C	P	C	P	C	P	C	P	C	P	C	P
HC: CA of 18 months (z-score)	−0.018	0.200	− 0.032	− 0.110	− 0.388	−0.343	0.403	−0.562	− 0.792* (0.006)	−0.429	− 0.216	−0.326	− 0.763* (0.010)	−0.172	− 0.309
Bayley score: 18 months of CA
Cognitive	−0.307	0.062	−0.294	−0.604	− 0.086	0.246	− 0.255	0.141	− 0.662* (0.037)	0.127	0.134	0.209	−0.090	−0.287	− 0.352
Language	−0.032	0.102	−0.204 (0.050)	− 0.270	−0.133	0.208	−0.270	− 0.117	−0.617* (0.058)	0.049	−0.151	0.177	−0.261	− 0.319	−0.328
Motor	−0.530* (0.016)	0.101	−0.330* (0.033)	−0.649 (0.058)	− 0.005	0.067	− 0.221	−0.052	− 0.749* (0.013)	0.008	0.267	0.100	−0.144	−0.120	− 0.445
Social emotional	−0.467* (0.038)	0.019	−0.222	− 0.764* (0.016)	0.383	0.420	−0.098	0.395	−0.452	0.554	−0.191	0.533	−0.252	− 0.152	−0.632 (0.050)
Adaptive	−0.325	0.119	−0.300	−0.405	− 0.186	0.202	− 0.083	−0.161	− 0.783* (0.007)	0.140	− 0.043	0.255	− 0.295	−0.074	− 0.504

Day 0: the day of inflammatory symptom onset

The values are Pearson correlation coefficient. If the p-value is less than 0.05, with (p-value). All values are adjusted for gestational age and postmenstrual age of inflammatory event

C Cerebrospinal fluid; P plasma; MBP Myelin Basic Protein; TNF alpha Tumor Necrosis Factor-alpha; HC head circumference; CA corrected age

* p < 0.05