Fig. 3.

a Adenoviral transduction is employed to modulate the human placenta-derived-MSCs for delivering endostatin. Such MSCs expressing human endostatin are homed into the cancer tissue and remarkably mitigate the size of tumor without considerable systemic toxic adverse effects. The beneficial effects in favour of tumor treatment are due to the promoted apoptosis of cancer cell as well as disturbed neovascularization, thereby decreased tumor cell proliferation and decelerated expansion. b Delivering the anti-angiogenic compounds resulted in normalization of the aberrant constructions and impaired function of the blood vessels, resulting in a remarkable diminished tumor-associated vasogenic brain edema, decreased vessel diameter and permeability was the underlying cause of the vessel normalization