Table 1:
Summary of Results of Fixed Ratio Self-Administration of Drugs Studied
| Drug | Peak Dose (mg/kg) | Avg.Max # of Injections/Session | ED50 Valueb (mg/kg [95% CI]) | DAT/SERT Selectivity |
|---|---|---|---|---|
| Cocaine | 0.01 | 40.3 | 0.0044 (0.0022–0.0089) | 1.25 |
| αPVP | 0.0032 | 38.8 | 0.0016 (0.0002–0.013) | 2893 |
| MCAT | 0.0032 | 41.2 | 0.0023 (0.00045–0.012) | 136 |
| MDPV | 0.0032 | 31.9 | 0.00062 (0.00031–0.0012) | 110 |
| Methylone | 0.1 | 34.4 | 0.013 (0.001–0.19) | 5.6 |
| MDMA | 0.032 | 21.1 | 0.055 (0.016–0.18) | 0.88 |
a
DAT selectivity values from Eshleman et al. 2017 calculated as 1/hDAT IC50:1/hSERT IC50
b
ED50 values with 95% Confidence Intervals of the ascending limb of the self-administration curves