Table 3.
Severe clinical outcomes of COVID-19 patients with allergic and non-allergic asthma and matched comparators.
| Outcomes | Allergic asthma (n = 260) | No asthma (n = 1252) | Non-allergic asthma (n = 302) | No asthmaa (n = 1434) |
|---|---|---|---|---|
| Hospitalization | ||||
| No. of events | 49 (19) | 230 (18) | 70 (23) | 257 (18) |
| Person days of follow up (mean, SD) | 60 (33) | 61 (33) | 56 (35) | 60 (33) |
| Rate of event per 1000 person days (95%CI) | 3.2 (2.3, 4.0) | 3.0 (2.6, 3.4) | 4.2 (3.2, 5.1) | 3.0 (2.6, 3.3) |
| Matched unadjusted (95%CI)a | 1.01 (0.76, 1.34) | 1.00 (ref) | 1.27 (1.00, 1.62) | 1.00 (ref) |
| Partially adjusted hazard ratio (95%CI)b | 0.93 (0.69, 1.24) | 1.00 (ref) | 1.22 (0.95, 1.56) | 1.00 (ref) |
| Fully adjusted hazard ratio (95%CI)c | 0.86 (0.64, 1.16) | 1.00 (ref) | 1.12 (0.83, 1.52) | 1.00 (ref) |
| Mechanical ventilation | ||||
| No. of events | 7 (3) | 55 (4) | 8 (3) | 52 (4) |
| Person days of follow up (mean, SD) | 72 (23) | 72 (24) | 71 (22) | 70 (24) |
| Rate of event per 1000 person days (95%CI) | 0.4 (0.1, 0.7) | 0.6 (0.4, 0.8) | 0.4 (0.1, 0.6) | 0.5 (0.4, 0.7) |
| Matched unadjusted (95%CI)a | 0.60 (0.28, 1.32) | 1.00 (ref) | 0.72 (0.34, 1.51) | 1.00 (ref) |
| Partially adjusted hazard ratio (95%CI)b | 0.61 (0.27, 1.37) | 1.00 (ref) | 0.69 (0.32, 1.46) | 1.00 (ref) |
| Fully adjusted hazard ratio (95%CI)c | 0.65 (0.28, 1.51) | 1.00 (ref) | 0.74 (0.31, 1.79) | 1.00 (ref) |
| Death | ||||
| No. of events | 6 (2) | 30 (2) | 1 (< 1) | 39 (3) |
| Person days of follow up (mean, SD) | 73 (21) | 74 (21) | 72 (20) | 73 (22) |
| Rate of event per 1000 person days (95%CI) | 0.3 (0.1, 0.6) | 0.3 (0.2, 0.4) | 0 (0, 0.1) | 0.4 (0.3, 0.5) |
| Matched unadjusted (95%CI)a | 0.92 (0.39, 2.16) | 1.00 (ref) | 0.12 (0.02, 0.88) | 1.00 (ref) |
| Partially adjusted hazard ratio (95%CI)b | 1.20 (0.47, 3.03) | 1.00 (ref) | 0.12 (0.02, 0.87) | 1.00 (ref) |
| Fully adjusted hazard ratio (95%CI)c | 0.82 (0.24, 2.75) | 1.00 (ref) | 0.06 (0.01, 0.71) | 1.00 (ref) |
COVID-19, coronavirus disease 2019; SD, standard deviation; CI, confidence interval.
Text in boldface indicates statistical significance, p < 0.05.
a
Age, sex, and date of SARS-CoV-2 diagnosis matched comparators.
b
Matched on age, sex, and date of SARS-CoV-2 test date and adjusted for age, sex, race, ethnicity, payor, and smoking status.
c
Matched on age, sex, and date of SARS-CoV-2 test date and adjusted for age, sex, race, ethnicity, payor, smoking status, body mass index, and Charlson comorbidity index.