Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 3:1–13. doi: 10.1080/13543776.2021.1880568

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Informa UK Limited, trading as Taylor & Francis Group

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

PMC Copyright notice

Figure 1. — Color-coded scheme and structure of the SARS-CoV nsp12 RdRp bound to nsp7 and nsp8 co-factors. (a) Diagram of the SARS-CoV nsp7, nsp8, and nsp12 proteins indicating domains and conserved motifs. (b) SARS-CoV nsp12 contains a large N-terminal extension composed of the NiRAN domain (dark red) and an interface domain (purple) adjacent to the polymerase domain (orange). nsp12 binds to a heterodimer of nsp7 (blue) and nsp8 (green) as well as to a second subunit of nsp8. Adapted (http://creativecommons.org/licenses/by/4.0/) from Kirchdoerfer et al. [12]. Color figure.