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Crystal structures of the SARS-CoV-2 (6XA9) and SARS-CoV PLpro (5TL6). The PLpro structures in complex with ISG15 are depicted and the ubiquitin-like protein is coloured cyan. The residues that surround the LXGG motif of ISG15 (5 Å) can be seen and the amino acids are coloured gold. The position of GRL-0617 within the binding site (coloured tan) is shown. The docked ligand can be seen in red and the interactions that were formed with this region are also provided.
