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. 2021 Mar 8:10.2217/nnm-2020-0441. doi: 10.2217/nnm-2020-0441

Figure 4. Hollow nanoparticles against coronavirus disease-19.

Figure 4.

(A) Fabrication of a nanovaccine based on synthetic biodegradable PLGA and DEPE-PEG polymers using a double emulsion technique. (B, C) Cryo-electron microscopy of cdGMP-loaded hollow nanoparticles. (D) Determination of the size distribution of nanoparticles via dynamic light scattering. HPLC diagram of adjuvant-loaded nanoparticles (NP[cdGMP]) and soluble cdGMP. (E) HPLC diagram of soluble cdGMP and adjuvant-loaded nanoparticles (NP[cdGMP]). (F) Calibration curve for the determination of cdGMP encapsulation efficiency. (G) cdGMP release profiles at pH 5 and pH 7.

PLGA: Poly (lactic-co-glycolic acid).

Reproduced with permission from [66] © WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim (2019).