Table 4.
Vitamin D related gene polymorphisms in EOAD/LOAD patients and controls.
| Genotype | AD | Control | Crude OR | p | Adjusted OR | pa |
|---|---|---|---|---|---|---|
| (95% CI) | (95% CI)b | |||||
| rs2282679A>C | AA/AC/CC | |||||
| Age <65 | 150/125/25 | 80/90/15 | 0.851 (0.851–1.135) | 0.272 | 0.845 (0.633–1.129) | 0.254 |
| Age ≥ 65 | 191/154/31 | 165/160/41 | 0.817 (0.655–1.018) | 0.072 | 0.822 (0.659–1.026) | 0.082 |
| rs10741657T>C | TT/TC/CC | |||||
| Age <65 | 47/130/123 | 17/83/85 | 0.783 (0.597–1.026) | 0.076 | 0.779(0.593–1.022) | 0.071 |
| Age ≥ 65 | 53/160/163 | 52/145/169 | 0.947 (0.772–1.162) | 0.600 | 0.956 (0.778–1.174) | 0.666 |
| rs12785878T>G | TT/TG/GG | |||||
| Age <65 | 42/155/103 | 46/93/46 | 1.544 (1.177–2.025) | 0.002 | 1.542 (1.176–2.023) | 0.002 |
| Age ≥ 65 | 92/180/104 | 81/178/107 | 0.927 (0.758–1.133) | 0.458 | 0.931 (0.761–1.138) | 0.484 |
| rs6013897T>A | TT/TA/AA | |||||
| Age <65 | 201/91/8 | 118/61/6 | 0.879 (0.627–1.231) | 0.452 | 0.877 (0.626–1.229) | 0.447 |
| Age ≥ 65 | 270/94/12 | 252/106/8 | 0.931 (0.707–1.226) | 0.611 | 0.924 (0.700–1.218) | 0.573 |
EOAD, Early-onset Alzheimer's disease; LOAD, Late-onset Alzheimer's disease; OR, odds ratio; CI, confidence interval.
a
Adjusted for sex.