Table 1.
Patient characteristics, surgery type and other intraoperative opioidsa
| Carbamazepine (N = 11) | Control (N = 6) | P value | |
|---|---|---|---|
| Characteristics | |||
| Female, n (%) | 5 (45) | 3 (50) | 0.72 |
| Age (years) | 49.5 ± 16.5 | 53 ± 17.6 | 0.67 |
| Weight (kg) | 72.6 ± 12.1 | 80.1 ± 4.2 | 0.43 |
| Height (cm) | 170 ± 9 | 172 ± 12 | 0.63 |
| BMI (kg/m2) | 24.7 ± 2.7 | 27.2 ± 8.1 | 0.41 |
| Creatinine (mg/100 ml) | 0.87 ± 0.11 | 0.73 ± 0.20 | 0.10 |
| eGFR (ml/min) | 107 ± 23 | 94 ± 15 | 0.57 |
| Albumin (g/100 ml) | 4.4 ± 0.2 | 4.3 ± 0.2 | 0.36 |
| Surgery type | |||
| Craniotomy for tumour | 4 (50) | ||
| Acoustic neuroma resection | 2 (25) | ||
| Microvascular decompression | 10 (91) | ||
| Other neurosurgical procedures | 1 (9) | 2 (25) | |
| Duration of surgery (min) | 257 ± 58 | 407 ± 163 | 0.01 |
| Intraoperative opioids | |||
| Alfentanil (mg) | 0.13 | ||
| Hydromorphone (mg) | 0.09 ± 0.3 | 0.26 ± 0.39 | |
| Meperidine (mg) | 2.27 | ||
| Morphine (mg) | 1.54 ± 3.5 | 1.25 ± 3.5 | |
| Remifentanil (mg) | 0.51 ± 0.87 | 0.36 ± 0.51 | |
| Sufentanil (mcg) | 17.5 ± 27.6 | 68.1 ± 57.2 | |
P values are from Student's t-test for independent groups. aValues are mean ± standard deviation, or number and per cent of total, as appropriate.