Table 2.
Pharmacokinetic variables for fentanyl
| Mean (±SD) value for | P valuea | ||
|---|---|---|---|
| Control (N = 6) | With carbamazepine (N = 11) | ||
| Central compartment volume | |||
| Litres | 35 (±33) | 42 (±42) | >0.5 |
| Litres/kg | 0.49 (±0.47) | 0.51 (±0.40) | >0.5 |
| Total volume of distribution | |||
| Litres | 258 (±91) | 422 (±270) | >0.15 |
| Litres/kg | 3.6 (±1.2) | 5.4 (±3.1) | >0.15 |
| Total AUC (ng/ml × min) | 233 (±70) | 150 (±65) | <0.02 |
| Clearance | |||
| ml/min | 919 (±242) | 1554 (±624) | <0.02 |
| ml/min per kg | 13.2 (±4.8) | 20.1 (±6.8) | <0.05 |
| Elimination half-life (h) | 3.28 (±0.89) | 3.09 (±1.34) | >0.5 |
| Distribution half-life (min) | 6.6 (±5.1) | 2.7 (±1.4) | <0.03 |
Bold numbers indicate statistically significant differences (P < 0.05)
a
Based on parametric or nonparametric test.