Flow of participants in the Exercise and Heart Project study of physical activity and cardiorespiratory fitness, São Paulo, Brazil, October 2001–October 2015. Levels of physical activity were defined as 1) inactive, 0 minutes per week; 2) insufficiently active, 1 to 149 minutes per week; 3) active, 150 to 299 minutes per week; and 4) very active, 300 or more minutes per week (6). Cardiorespiratory fitness level was assessed by the 2-minute step-test and classified based on quartiles of the total sample as follows: quartile 1, 87 or fewer steps; quartile 2, 88 to 101 steps; quartile 3, 102 to 114 steps; and quartile 4, 115 steps or more.