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. 2021 Mar 5;7(1):e001494. doi: 10.1136/rmdopen-2020-001494

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Fibrocytes in in vitro culture (A and B) and in the synovium (C, D, E and F). (A and B) PBMCs cultured for 5 days with interleukin-4. (B) Higher magnification, with black arrows marking fibrocytes, red arrows marking macrophages, white marking a dendritic cell and yellow marking lymphocytes. (C, D, E and F) Synovial tissue stained with CD45 (purple) and α-smooth muscle actin (yellow), double-positive cells (fibrocytes) with dark arrows. (D) With low-grade inflammation and (C, E and F) with severe inflammation showing a high influx of lymphocytes around the vessels.