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. 2021 Mar 7;9(3):e001717. doi: 10.1136/jitc-2020-001717

Figure 1.

Figure 1

Methodology for evaluation of tumor cell density (TCD) and allocation of radiotherapy response categories. (A) Virtual graticule of approximately 300 points applied to tumor area on a digital H&E section. (B) Demonstration of TCD point scoring. (C) Box and whisker plot to show the relationship between ΔTCD and American Joint Committee on Cancer (AJCC) Tumour Regression Grade System (TRG). (D, E) Allocation of three radiotherapy response groups according to change in TCD (ΔTCD) for short-course radiotherapy (SCRT) (D) and long-course chemoradiotherapy (LCRT) (E). The Kruskall-Wallis test was used for statistical comparisons.