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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: JCSM Rapid Commun. 2020 Aug 7;4(1):3–15. doi: 10.1002/rco2.18

Figure 7.

Figure 7.

Media from LLC cancer cells reduces resistance to hypoxic insult in cardiomyocytes. (A) H9c2 cells were treated with a combination of LLC media (LCM) and 2μM of the mitochondrial targeted antioxidant (MitoT) for 24 hours and exposed to 1% oxygen and serum-free media for 6 hours followed by MTT viability assessment. * indicates p < 0.05 vs. control media (CM) with no MitoT (con); † indicates p < 0.05 vs. con cells receiving same media condition; dashed line at 100% indicates control cells that were maintained ~21% O2 in standard growth media. (B) Graphical representation of suggested relationship between cancer-induced cardiac atrophy and oxidative characteristics.