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. Author manuscript; available in PMC: 2021 Nov 25.
Published in final edited form as: Adv Funct Mater. 2020 Jun 8;30(48):2000545. doi: 10.1002/adfm.202000545

Figure 2: Co-culture of fibroblasts with pancreatic tumor organoids results in dense tissues with larger organoids.

Figure 2:

A) Brightfield images showing the compaction of extracellular matrix of fibroblast mono-culture control tissue, organoid mono-culture tissue, and organoid/FB co-culture tissues over 8 days. Scale Bar, 200μm. B) Size distribution of individual organoids in organoid tissues and organoid/FB co-culture tissues. C) Average organoid diameter in vascularized organoid tissues and vascularized organoid/FB co-culture tissues. (Data are mean ± SD, **** p < 0.0001, N = 5 tissues, tissues were generated from two separate seeding settings, n = 40 organoids from each tissues were measured, unpaired student’s t-test was used).