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. Author manuscript; available in PMC: 2021 Nov 25.
Published in final edited form as: Adv Funct Mater. 2020 Sep 11;30(48):2004119. doi: 10.1002/adfm.202004119

Figure 3.

Figure 3.

Biomaterials can be designed to improve uptake and processing by APCs. A) Pickering emulsions allow for improved deformability, which facilitates uptake of NPs by APCs. Reproduced with permission.[67] Copyright 2018, Nature Publishing Group. B) Time-lapse microscopy analysis of NPs to observe cell-particle interactions. Rigid constructs have prolonged interactions with cells compared to soft constructs. Reproduced with permission.[69] C) Functionalization of polyanhydride NPs with di-mannose via a glycolic acid linker to mimic bacterial surfaces promotes internalization of NPs. Enhanced uptake is observed even with the glycolic acid alone. Copyright 2018, American Chemical Society. Reproduced with permission.[75] D) Modification of a single amino acid can alter intracellular processing. Reproduced with permission.[80] Copyright 2018, American Chemical Society.