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. 2021 Mar 3;41(9):2053–2068. doi: 10.1523/JNEUROSCI.1946-20.2021

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Copyright © 2021 Shimobayashi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — Behavior analysis shows motor deficit and ataxic phenotype in PKCγ-A24E mice. A, The beam test was done in 3- and 6-month-old mice. Slip count of Wt (1.235 ± 0.271, n = 28), Het (9.265 ± 1.079, n = 28, p < 0.0001), and Homo PKCγ-A24E mice (17.50 ± 0.056, n = 28, p < 0.0001). Data are mean ± SEM. Statistical significance of the values of Wt and PKCγ-A24E mice groups was analyzed by two-way ANOVA test with Bonferroni correction: ****p < 0.0001. B, C, Rotarod performance test was evaluated in 3-month-old mice (B) and 6-month-old mice (C). B, Latency to fall on day 4: Wt = 17.00 ± 2.000 rpm, n = 11; Het = 18.00 ± 1.528 rpm, n = 14; Homo = 4.333 ± 1.212 rpm, p < 0.0001, n = 14 and on day 5: Wt = 24.33 ± 1.202 rpm, n = 11; Het = 14.67 ± 1.202 rpm, p = 0.0317, n = 14; Homo = 6.67 ± 0.667 rpm, p < 0.0001, n = 14. C, Latency to fall on day 3: Wt = 13.60 ± 2.227 rpm; Het = 8.200 ± 1.241 rpm, p = 0.0127; Homo = 5.200 ± 0.374 rpm, p < 0.0001; n = 5 for each genotype and on day 4: Wt = 15.80 ± 2.200 rpm; Het = 12.60 ± 1.749 rpm; Homo = 7.80 ± 0.735 rpm, p = 0.0002; n = 5 for each genotype. Data are mean ± SEM. Statistical significance of the values of Wt and PKCγ-A24E mice groups was analyzed by two-way ANOVA test with Bonferroni correction: *p < 0.05; ***p < 0.001; ****p < 0.0001. D, Footprints of 9-month-old Wt and PKCγ-A24E mice were evaluated for step width. E, Wt = 1.30 ± 0.058 cm, n = 12; Het = 2.60 ± 0.154 cm, n = 12; Homo = 2.95 ± 0.047 cm, n = 12. Data are mean ± SEM. Statistical significance of the values of Wt and Het or Homo PKCγ-A24E mice groups was analyzed by two-way ANOVA test with Bonferroni correction: ****p < 0.0001.