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. 2021 Mar 3;41(9):2039–2052. doi: 10.1523/JNEUROSCI.1952-20.2020

Figure 4.

Figure 4.

STN DBS does not impact PFF-inclusion associated loss of TH phenotype in nigral neurons in PFF-treated rats one or two months after injection. Whole nigra stiched images A, B, G, H and high-magnification ipsilateral boxed insets (C, E, D, F, respectively) of THir neurons two months after PFF treatment. Quantification of nigral THir neurons in rats without (INACTIVE) and with (ACTIVE) STN DBS one month (I) and two months (J) after PFF treatment demonstrate an inclusion-associated decrease that is not affected by stimulation status. INACTIVE (A, C) and ACTIVE (G, D) PBS-treated rats were statistically similar and combined (J). Contralateral THir counts were not different across groups. Ipsilateral THir counts were decreased in both INACTIVE (B, E) and ACTIVE (H, F) PFF-treated rats compared with their contralateral side or PBS-treated controls (J). Loss of TH phenotype in the SN was not associated with neurodegeneration as measured by HuC (pan neuronal marker; K). Scale bars: 100 µm; *p ≤ 0.05, **p ≤ 0.01. Values represent the mean ± SEM.