Table 1.
Comparison of Molecular and Behavioral Abnormalities in SZ and BP Disorder Patients With the Mouse MET and PRS Models of Psychiatric Disease.
| SZ + BP Patients | MET Mice | PRS Mice | |
|---|---|---|---|
| Molecular changes | |||
| DNMT1, DNMT3a, TET expression | ↑ | ↑ | ↑ |
| DNMT1 or MECP2 binding to GAD1, RELN, BDNF promoters | ↑ | ↑ | ↑ |
| 5mC, 5hmC enrichment at RELN or GAD1 | ↑ | ↑ | ↑ |
| Candidate gene (GAD1, RELN, BDNF) expression | ↓ | ↓ | ↓ |
| Behavioral changes | |||
| Positive symptoms (stereotyped behavior, sensitivity to NMDA receptor antagonist) | ↑ | ↑ | ↑ |
| Negative symptoms (social interaction deficits) | ↑ | ↑ | ↑ |
| Cognitive, information processing deficit (PPI, fear conditioning) | ↑ | ↑ | ↑ |