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. 2021 Mar 5;100(9):e24906. doi: 10.1097/MD.0000000000024906

Figure 3.

Figure 3

(A) Forest plot for the incidence of bacterial colonization of tracheal aspirate. (B) Trial sequential analysis for the incidence of bacterial colonization of tracheal aspirate. Risk of type 1 error was maintained at 5% with a power of 90%. The variance was calculated from the data obtained from the included trials. A clinically meaningful risk ratio was set at 0.75. The blue line is the cumulative Z curve, and each black square dot represents 1 trial. The brown horizontal lines indicate a conventional significant P value of .05. The red diagonal lines represent the futility region. The red vertical lines are the trial sequential monitoring boundaries. In total, 1050 patients were analyzed, and the Z curve did not cross the monitoring boundary. CI = confidence interval, PU = polyurethane, PVC = polyvinyl chloride, RIS = required information size, RR = relative risk, SSD = subglottic secretion drainage.