Table 4.

The causes of death of insulin vs glimepiride groups in patients with background metformin therapy.

	Metformin		Insulin vs glimepiride
	Glimepiride n (%)	Insulin n (%)	Adjusted HR (95% CI)	P value
Causes of CV death	2 (0.20)	10 (0.97)	7.95 (1.65–38.3)	.01
Ischemic heart disease	0	1
Sudden cardiac death	0	3
Heart failure	1	1
Stroke	1	2
Cardiovascular procedure
Cardiovascular hemorrhage	0	3
Other cardiovascular causes
Non-cardiovascular causes of death	13 (1.27)	142 (13.83)	14.9 (8.4–26.3)	<.001
Cancers	3	52
others	10	90
Undetermined	1 (0.10)	14 (1.36)	23.9 (3.1–184)	.002