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. 2021 Jan 13;295(52):18199–18212. doi: 10.1074/jbc.RA120.016049

Figure 1.

Figure 1

Q/R editing site at exon 20 and alternative splicing of exon 4 in Tmem63b pre-mRNA.A, domain structure of the mouse Tmem63b protein. The transmembrane domains (M0 to M10) are depicted in blue with linking regions in light blue. The A-to-I editing (red line) is at the intracellular linker adjacent to M7. The alternative splicing exon 4 (green block) encodes amino acids in the first intracellular loop. SP, signal peptide. Scale bar, the size of the line diagram. B, schematic representation of Q/R editing site at exon 20. Lower-left shows the sequence of the Q/R site cloned from mouse brain cDNA. Lower-right shows the cloned sequence (CLONE-1) compared with documented Tmem63b mRNA sequence NM_198167. The corresponding amino acids are shown above and under the nucleotide sequences. C, schematic representation of Tmem63b exons 3–5. The comparison between cloned sequence (CLONE-1) and documented Tmem63b sequence is shown below. The corresponding amino acids are shown above and under the nucleotide sequences.