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Cell viability and cell cycle effects of tenovins upon supplementation with nucleotides.A–G, ARN8 cells treated for 72 h with compound or treated for 72 h followed by compound wash-out and recovery in fresh medium for 24 h. H, ARN8 cells treated for 48 h with the indicated compounds at 10 μm (tenovins 1 and 33) or 200 nm (brequinar) with or without supplementation with 100 μm uridine, 1 mm DHO, or 1 mm OA.
