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. 2021 Jan 13;295(52):18539–18552. doi: 10.1074/jbc.RA120.016149

Figure 9.

Figure 9

Structure comparison of the catalytic sites of Pc1,3Gal43A (A), GH55 exo-β-1,3-glucanase from P. chrysosporium (B; PcLam55A; PDB code3EQO), GH55 exo-β-1,3-glucanase from Streptomyces sp. SirexAA-E (C; SacteLam55A; PDB code4PF0), and GH3 β-glucosidase from H. jecorina (D, HjCel3A; PDB code3ZYZ). A, B, and C hydrolyze the main chain of β-1,3-galactan or β-1,3-glucan, bypassing β-1,6–branched side chains (6, 29, 30). D hydrolyzes four types of β-bonds, and it does not bypass side chains (31, 52). The top panel shows the overall surface structure, and the bottom panel shows an enlarged view of the catalytic region. Orange dashed circles, space near the C-6 position of Gal or glucose at the nonreducing end.