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. 2021 Mar 4;14:1707–1718. doi: 10.2147/OTT.S300623

Figure 3.

Figure 3

Validation of the identified association of CA12 transcription level with clinicopathological factors using TCGA database. The landscape of CA families and their relationship between diverse diagnostically relevant clinicopathological factors in TCGA Database (A). High CA12 mRNA levels significantly associate with WHO IV grade (B), IDH1 wildtype DNA status (C), tumors with 1p/19q chromosome arm co-deletion (D) and CA12 tumors carrying de-methylated MGMT promoter region (E). CA12 mRNA is significantly upregulated in the most aggressive mesenchymal subtype of GBM (F).