Figure 5.
Pharmacological targeting of CAXII in glioma in vitro functional responses. 6A10 treatment did cause mild inhibitory effect on cell growth in subset of tested GSC models/GBM1 and BTSC407, and no effect on BTSC233, unb = control (A–C). All cells are IDH1wt and MGMT promoter methylated, GBM1 and 407 are classical subtype of GBM, BTSC233 is mesenchymal subtype of GBM (data not shown). 6A10 treatment caused suppression of cellular invasion in responder cell line GBM1 but not in non-responder model 407 (D and E), BTSC233 not tested.