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. 2021 Mar 4;13:303–313. doi: 10.2147/NSS.S293160

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© 2021 Guay et al.

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Decision tree during sedation protocol. In all cases, the sedation protocol will begin with the targeting of effect site and plasma dexmedetomidine concentrations of 2 ng/mL via TCI. In the event that slow-waves are not observed in the EEG, the target concentration will be increased in increments of 1 ng/mL to induce EEG slow-waves. If a participant with slow-waves continues to perform the behavioral task, they will proceed to light CLASS, after which the dexmedetomidine TCI is increased in increments of 1 ng/mL until they stop performing the task. This is followed by the deep CLASS, arousal, and recovery phases.